Skip to content

New approach to
calcification disorders


Who we are

Sanifit is a clinical-stage biopharmaceutical company focused on treatments for progressive vascular calcification disorders. The company is a spin-off from the University of the Balearic Islands, and has offices in Spain and the U.S. Sanifit’s lead compound, SNF472, is a novel small molecule, and a selective and potent inhibitor of hydroxyapatite (HAP) crystallization, the final common pathway that leads to vascular calcification. Its clinical development is focused on two indications in End Stage Kidney Disease (ESKD) patients; calciphylaxis and peripheral artery disease (PAD).

The company conducted a Phase 2b trial (CaLIPSO) to assess the effect of SNF472 on slowing arterial calcification, a major risk factor for cardiovascular diseases in patients on dialysis. The trial met its primary endpoint in reducing coronary artery calcium progression in patients treated with SNF472 compared to patients receiving placebo over a 52-week period.

SNF472 is in Phase 3 clinical development for the treatment of calciphylaxis or CUA (calcific uremic arteriolopathy) in ESKD patients that will measure two alternate primary endpoints – wound healing and pain. SNF472 is orphan designated for the treatment of calciphylaxis by FDA and EMA.

A phase 3 trial in Peripheral Arterial Disease in ESKD will launch in 2021. PAD in ESKD is driven by progressive calcification of peripheral arteries and disease progression can lead to reduced walking ability, claudication and amputations.


Mr. Antonio Jiménez

General Counsel & VP Operations

 Dr. Marco Antonio Moreno

SVP Manufacturing

Dr. Laurence H. Keller

VP Clinical Development

 Ms. Marisa Guitart

Head of Business Operations


A company belonging to the group

Public Funds

Número de proyecto: RTC-2014-2460-1
Nombre del Ministerio: Ministerio de Ciencia, Innovación y Universidades




ParcBIT – Ctra Valldemossa km7.4
Building Europa, 2nd floor
07121 Palma


 +34 971 439 925

Sanifit ParcBIT – Ctra Valldemossa km7.4
Building Europa, 2nd floor
07121, Palma de Mallorca (Illes Balears)
Sanifit USA - 3655 Nobel Drive Suite #540
San Diego, CA 92122